The textile and clothing sector is an important part of the European manufacturing industry, playing a crucial role in the economy and social well-being in many regions of Europe. According to data from 2013, there were 185 000 companies in the industry employing 1.7 million people and generating a turnover of EUR 166 billion. The sector accounts for a 3% share of value added and a 6% share of employment in total manufacturing in Europe.
The sector in the EU is based around small businesses. Companies with less than 50 employees account for more than 90% of the workforce and produce almost 60% of the value added.
The biggest producers in the industry are the five most populous EU countries: Italy, France, the United Kingdom, Germany, and Spain. Together, they account for about three quarters of EU production. Southern countries such as Italy, Greece, and Portugal; some of the new EU countries such as Romania, Bulgaria, and Poland; and, to a lesser extent, Spain and France, contribute more to total clothing production. On the other hand, northern countries such as the United Kingdom, Germany, Belgium, the Netherlands, Austria, and Sweden contribute more to textile production, notably technical textiles.
With regards to external trade performance, about 20% of EU production is sold outside the EU despite limited access to many non-EU markets.
The fashion and high-end industries represent European cultural heritage and expertise. With 5 million people directly employed in the fashion value chain and over 1 million people employed in the high-end industries, these activities provide an important contribution to the EU economy.
The fashion and high-end industries are one of the most vibrant and creative sectors in Europe. They are present in the everyday life of millions of people and act as ambassadors of European values, such as culture, creativity, innovation, and craftsmanship.
These industries form complex and interlinked value chains from the design and manufacturing of fashion goods (such as textiles, clothing, footwear, leather, fur products, jewellery, and accessories) and high-end goods, to their distribution and retail.
Despite the economic crisis, many European companies in the sector have managed to defend their position in the global market. This is mainly due to a move towards innovative, high added-value products and services, niche markets, and new business models.
The high-end sector grew faster than the rest of the European economy during the crisis, recording double digit growth in 2010 and 2011. High-end industries alone employ over 1 million people, export over 60% of their production outside Europe, and account for 10% of all EU exports.
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PHARMACEUTICAL
Top 10 European Biopharma Clusters
According with McKinsey, total investment of all types (Venture Capital (VC), initial public offerings, follow-on public offerings) in European biotechs more than doubled during 2012–2018, when €11.9 billion ($13 billion) in investment was recorded, compared with €5.1 billion ($5.6 billion) in 2005–2011. VC activity more than tripled from period to period, reaching $2.3 billion, “thanks to the emergence of bigger, stronger European VC funds”.
Between 2012–18, the U.S. originated about three times as many patent registrations for new medicines as Europe did, while China originated about nine times as many as Europe.
Patents and VC financing are among the five criteria used by GEN to rank countries in its annual A-Lists of top European biopharma clusters:
- Patents - Based on the number of “biotechnology” and “pharmaceutical” patents granted to, plus biotech and pharma patent applications made by, countries in Europe, as furnished by the publicly available European Patent Office database of granted patents per field of technology and per country of residence during 2018.
- Venture Capital (VC) funding - Combines figures compiled by Invest Europe with figures furnished by some of the countries themselves, either on their own websites, in publicly available reports, in public announcements, or as responses to email queries from GEN.
- Public research funding - Figures taken from the publicly available European Union Community Research and Development Information Service (CORDIS) website of grants issued through the current Horizon 2020 research funding program (2014–2020).
- Number of biotech companies - Combines figures furnished by representatives of the countries themselves, either on their own websites, in publicly available reports or public announcements, in news reports, or as responses to email queries from GEN. Where known, figures reflect companies with an “exclusive” or “pure” focus on biotech.
- Jobs - Based on various sources from industry groups, regional life sciences campuses, public and/or private economic development groups, and press articles when written by or directly attributed to an industry source. Where possible, medical device or “medical technology” job numbers normally included in “life sciences” employment numbers were excluded, leaving job numbers more closely focused on biotech and pharma.
This year’s European cluster ranking includes all countries that appeared on GEN’s 2018 A-List of top 10 European biopharma clusters, but with several significant changes, including a new number-four nation and much of the bottom half of the list. Two countries just missed making this year’s list despite top-10 rankings in selected areas: Ireland placed 10th in VC (€69.369 million [$76.2 million], according to Invest Europe), while Austria’s 10th-place ranking came in public financing (2,193 grants).
Top-10 rankings in venture capital: Ireland ranked seventh (€80.15 million [$92.1 million]), and Austria, eighth (€69.061 million [$79.4 million]), both according to Invest Europe (formerly known as EVCA; European Private Equity and Venture Capital Association).
TOP 10. Sweden
Three officials—Minister of Enterprise Ibrahim Baylan, Minister for Higher Education and Research Matilda Ernkrans, and Minister for Health and Social Affairs Lena Hallengren—raised hopes within Sweden’s life sciences industry in June by publishing a commentary in Dagens Medicin advocating a strategy that would raise the country’s profile worldwide. Sweden took the first such step last year by creating a government Office of Life Sciences tasked with developing such a strategy. In November 2018, the nation published a status report or Life Sciences Road Map urging Sweden to focus beyond drug development, into digital healthcare and health data, precision medicine, and “tomorrow’s health and social care.”
While the strategy is still in the works, Sweden’s government delivered some good news to the industry in the 2020 budget bill submitted September 18—it plans a further cut in fees for employers that carry out R&D in order to stimulate innovation, though details have yet to be presented. The strategy is intended to build upon assets that range from academia (Karolinska Institute and Lund, Uppsala, and Göteborg Universities) to industry (and from giants like AstraZeneca and Pfizer-acquired Pharmacia to smaller biotechs).
Sweden ranks sixth in number of companies (566, according to the Swedish Life Sciences Database, whose partners include industry group Sweden Bio and SWELife—the government-funded life-sciences strategic innovation program. The country is also sixth in jobs (40,000, according to Sweden’s R&D funding agency Vinnova), but ninth in public research funding (2,380 grants), 10th in patents (93 granted and 173 applications in 2018), and 11th in VC (€38.267 million [about $41.9 million], according to Invest Europe.
TOP 9. Denmark
Bagsværd-based Novo Nordisk made history September 20 when the FDA approved the company’s Rybelsus® (semaglutide) for type 2 diabetes in adults—the first U.S.-approved oral glucagon-like peptide-1 (GLP-1) receptor agonist. Five months earlier, Novo Nordisk signaled its intent to manufacture that and other next-generation diabetes treatments in Denmark by announcing a DKK 650 million ($95 million) expansion of its half-century-old production site in Kalundborg. The expanded site is set to begin production in 2020.
Novo wasn’t the only Danish biotech succeeding with the FDA. On September 24, the agency authorized Copenhagen-based Bavarian Nordic’s smallpox and monkeypox treatment Ynneos™. Another home-grown biotech, Copenhagen-based Genmab, raised approximately $546.5 million in net proceeds in July through a U.S. initial public offering of American Depositary Shares on the Nasdaq Global Select Market. And in September, Medicon Valley Alliance, which oversees a mini-cluster linking the Greater Copenhagen region of eastern Denmark to southern Sweden, lost its chairman Søren Bregenholt, PhD, after he was appointed CEO of U.K.-based Macrophage Pharma.
Denmark’s number of biopharma companies (536, the Ministry of Foreign Affairs or MFA told GEN) place the country fifth. Denmark is sixth in patents (156 granted and 465 applications in 2018), but eighth in jobs (30,869, according to the MFA), ninth in VC (€72.705 million [$79.5 million], according to Invest Europe), and 11th in research funding (1,999 grants).
TOP 8. Belgium
One of Belgium’s best-known drug developers, Mechelen-based Galapagos, showed this summer that European biopharmas are just as capable of scoring big-money collaboration deals as their counterparts in the U.S. or Asia. Gilead Sciences on July 14 said it will invest $5.1 billion to nearly double its minority stake in Galapagos from approximately 12.3% to at least 22%—and possibly about 30%—through a 10-year global R&D collaboration in which Gilead will expand its role in the companies’ arthritis candidate filgotinib and co-develop the rest of Galapagos’ pipeline.
Galapagos is an industry anchor within Belgium’s Flanders region, where Mont-Saint-Guilbert-based Promethera Biosciences in May dosed its first patient in a Phase IIa trial of its HepaStem, which according to the company is the world’s first liver stem cell therapy candidate for late-stage NASH. In the Wallonia region, Gosselies-based CDMO MaSTherCell said in March it will triple its European capacity by building a new manufacturing site for late-stage and commercially-approved gene therapies. The facility is set to open in 2021. Wallonia’s bioindustry group BioWin is even reaching out beyond Belgium, inking a cross-membership agreement with French counterpart Medicen Paris Region.
Belgium scores highest in jobs, ranking fifth (46,500, based on the 26,500 Wallonia jobs and 20,000 Flanders jobs cited by regional groups), with EFPIA counting 35,711 pharmaceutical jobs. The country is seventh in public research finding (3,401 grants) and VC (€129.366 million [$141.5 million], according to Invest Europe), but ranks lower in patents (eighth with 138 granted and 315 applications in 2018), and number of companies (10th with 308 according to Biotechgate, presumably including the 157 tallied in Wallonia by BioWin).
TOP 7. Italy
While Italy’s politics remain turbulent, reflected in the August resignation of Prime Minister Giuseppe Conte, the nation’s biopharma industry shows signs of smoother sailing, reflected in its rising two positions in this A-List compared with 2018. Italy places fifth in research funding (5,434 grants) and venture capital, where it has leaped from 11th last year to fifth (€157 million [about $172 million], Italy’s ENEA, the Italian National Agency for New Technologies, Energy and Sustainable Economic Development told GEN). Italy ranks lower in patents (seventh with 177 granted and 256 applications in 2018), number of companies (ninth with 319 according to ENEA), and jobs (10th with 8,599, according to ENEA).
On September 11, Milan-based Genenta Science Thermo raised €13.2 million ($14.4 million) in a private financing to fund a pair of ongoing Phase I/II trials for its cancer stem cell therapy Temferon. One trial will assess patients with solid tumor glioblastoma multiforme; the other, patents with multiple myeloma. The financing brings Genenta’s total capital raised to €30.2 million ($33 million). Among companies growing in Italy is Thermo Fisher Scientific, which in March revealed plans to expand sites in Monza and Ferentino, Italy, as well as Greenville, NC, as part of a $150 million Pharma Services investment designed to add capacity for sterile liquid and lyophilized product development and commercial manufacturing.
TOP 6. Switzerland
Lausanne-based ADC Therapeutics, the developer of antibody drug conjugates targeting major cancers, withdrew a planned IPO on the New York Stock Exchange on October 2, but not before disclosing plans to raise up to approximately $205.9 million in net proceeds. Another home-grown biotech, Basel-based Roivant Sciences—owner of 20 companies or “vants”—in September sold five of those companies to Sumitomo Dainippon Pharma for $3 billion upfront. The megadeal gave Sumitomo Dainippon a more-than-10% stake in Roivant, and an alliance overseeing more than 25 clinical programs and multiple potential product launches through 2022.
Yet the biggest headlines from Swiss biopharmas have come from a pharma giant. Basel-based Novartis’ AveXis gene therapy subsidiary in May won FDA approval for Zolgensma® (onasemnogene abeparvovec-xioi), a treatment for pediatric spinal muscular atrophy. Soon after, Novartis generated controversy by pricing the gene therapy at a list price of $2.1 million, though it added that it was working with insurers to develop patient access programs.
Switzerland scores highest in patents (third with 341 granted and 925 applications in 2018), and next-highest in venture capital (fourth with CHF 252.6 million [$254.9 million] according to the 2019 Swiss Venture Capital Report by Startupticker.ch with SECA [Swiss Private Equity & Corporate Finance Association]). However, the nation ranked eighth in research funding (2,544 grants), ninth in jobs (14,319, according to Swiss Biotech Association), and 11th in number of companies (249, also according to Swiss Biotech Association).
TOP 5. The Netherlands
The Netherlands has actively positioned itself to gain from the U.K.’s pain over Brexit. In August, the Netherlands Foreign Investment Agency (NFIA) announced that 98 companies were worried enough about the U.K.’s future to move to the Netherlands. “Health and life sciences” are among the industries that U.K. companies are most attracted to in Holland. No doubt those companies are being drawn by closer proximity to the European Medicines Agency, which in March moved its offices to Amsterdam from London.
Among biotechs recently making news in the Netherlands is U.S.-based Fujifilm Irvine Scientific, a leading developer and manufacturer of cell culture media, which in July announced plans to open a European hub in Tilburg; the cGMP manufacturing facility will be the company’s third worldwide. Most recently on October 2, Lonza said its GMP facility in Geleen will oversee clinical manufacturing of Paris-based Cellectis’ allogeneic UCART product candidates targeting hematological malignancies.
The Netherlands’s rankings show consistency, ranging between fifth in patents (185 granted and 593 applications in 2018), and seventh in jobs (“over 34,000,” according to NFIA’s website) and number of companies (512, according to NFIA, which cites Holland BIO’s Dutch Life Science Database). In between, the country places sixth in grants (4,264) and venture capital (€134.479 million [$147.1 million], according to NVP, the country’s private equity and venture capital association).
TOP 4. Spain
The Spanish Association of Biotech Companies, ASEBIO, reported some record-breaking numbers from its Investor Day event held September 25–26: Sixty investors from nine countries attended the event, providing more than 500 partnering opportunities for the 280 participating companies. ASEBIO is hoping that activity translates into more financings: Spain ranked eighth in VC last year with nearly €95 million (about $104 million)—though the amount of VC investment by overseas firms has nearly doubled from €40 million (nearly $44 million) in 2016 to €74 million ($81 million) last year.
Beyond venture capital, Spain ranks ninth in patents (95 granted and 299 applications in 2018). The nation ranks much higher at fourth in both number of companies (713) and jobs with a combined 67,716 (42,687 pharma jobs according to EFPIA, and 25,029 biotech jobs according to ASEBIO). Yet Spain’s brightest spot is public funding, where it reached third with 6,154 grants.
Another strength of Spain is diagnostics development: In May, a respiratory diagnostic panel originally developed by Barcelona-based STAT-Dx won FDA approval, more than a year after STAT-Dx was acquired by Qiagen for up to $191 million. Spain can also expect to see more biomanufacturing since Grifols revealed plans in May to build new manufacturing facilities in Murcia (products for the U.S. market) and Llica de Vall, Barcelona province (addition to plant in Parets), part of a €1.4 billion [$1.5 billion] companywide investment through 2022.
TOP 3. France
President Emmanuel Macron committed France to becoming a “start-up nation” when he took office in 2017. Macron announced plans for a €5 billion (about $5.5 billion) development fund designed to support early-stage digital health and other tech companies. The fund could help France achieve another ambitious goal articulated last year by Macron—becoming a global leader in AI by spending €1.5 billion ($1.6 billion). Macron also seeks to reduce red tape for early-stage companies.
Two home-grown companies reported successes in April. Paris-based Cellectis in April won FDA approval for its IND to begin a Phase I trial of UCARTCS1, the first allogeneic CAR-T therapy for multiple myeloma to enter clinical development. Lyon-based Calixar licensed its native membrane protein stabilization technology to Regeneron Pharmaceuticals.
France advanced last year to second in VC (€594 million [$649.8 million], France-Biotech told GEN) while staying second in patents (416 granted and 866 applications in 2018). The nation dipped to fourth in research funding (5,581 grants), but is third in number of companies (720, according to France Biotech) and jobs (98,694 pharma jobs according to pharma industry group LEEM [Les Enterprises du Medicament], down 92 from a year ago, and about 20,000 biotech jobs, according to France Biotech.
TOP 2. Germany
“Germany is Europe’s great untapped player in biotech,” Richard Mason, MD, co-founder of the Foundation Institute for 21st Century Medicine, recently told Pharmaceutical Market Europe. Mason headed XO1 until its 2015 acquisition by Johnson & Johnson—which later tapped him to head J&J Innovation’s London Innovation Centre. “While Germany has produced far fewer biotech companies than you would expect, it’s definitely the place to watch.”
Impostos e burocracia podem de fato ter impedido a criação de startups, como afirma Mason. Mas o Ministério Federal de Educação e Pesquisa (BMBF) incentiva a tradução de pesquisas em novas empresas por meio do GO-Bio, lançado em 2005. Empresas maiores de origem doméstica tiveram sucesso: a BioNTech planeia arrecadar até US $ 267,8 milhões em receitas líquidas através de um um IPO lançado no American Depositary Shares - NASDAQ Global Select market. Em 24 de setembro, a Evotec, com sede em Hamburgo, lançou uma parceria com a Takeda Pharmaceutical para desenvolver pelo menos cinco candidatos a medicamentos, com a Evotec a receber uma taxa inicial não revelada, até US $ 170 milhões por programa, e royalties diferenciados.
Germany maintains its number-one rankings in patents (605 granted and 1,360 applications in 2018) and jobs (130,902 pharma jobs according to the German Association for the Pharmaceutical Industry [BPI], and 27,445 biotech jobs according to BIO Deutschland). The federal republic placed second in research funding (6971 grants), second in companies (1,232) and rose one position to third in VC (€369 million [$403.7 million], according to BIO Deutschland).
TOP 1. United Kingdom
UK’s government has committed £434 million ($533.3 million) toward shipping and storage to prevent shortages of medicines and medical products upon a pullout from the EU. The U.K. BioIndustry Association (BIA) has stepped up its Brexit webinar briefings from monthly to weekly.
In May, the BIA and the Medicines Discovery Catapult showed strong growth potential where drug discovery is concerned, in a report that found the segment could support an additional 33,000 jobs and 50 early clinical stage companies by 2025. It helps that the U.K. leads Europe in biopharma VC (£1.113 billion [about $1.4 billion], according to the BIA.
The U.K. is also top-ranked in public funding (7,981 Horizon 2020 grants) and number of companies (2,153 biopharmas, according to Bioscience and Health Technology Statistics 2018). The U.K. is second in biopharma jobs (about 121,000, including biopharma service and supply jobs), but fourth in patents (276 granted and 549 applications in 2018).